Paleo Diet Q & A - 3 February 2010 - Milk During Pregnancy

Dear Readers,

Today's edition of Paleo Diet Q & A focuses on consumption of milk during pregnancy.

Q: Hi Dr. Cordain,

My sister is a few weeks pregnant and has been following the Paleo Diet for a couple months now. Her doctor just told her to consume lots of milk during her pregnancy. My assumption is that they want to make sure she's getting plenty of vitamin D and calcium. I have her on a 2000 IU/day vitamin D supplement as well as a calcium/vitamin D supplement. What are your thoughts/suggestions?

Drew

A: Dear Drew,

There is good evidence that up until 9,000 years ago in the Middle East¹ and 7,000 years ago in Northern Europe², no human being on the planet consumed non-human milk or dairy products.

So, on an evolutionary time scale non-human milk is a relative newcomer to the human diet.

By using the evolutionary template, and knowing that milk is species-specific, we would expect this new habit to have unintended consequences, which go much beyond lactose intolerance, which is, actually very common, since only a minor percentage of the world’s population continues to produce lactase into adulthood³.

Indeed there are several lines of evidence raising concerns with milk and dairy intake, such as:

1) Milk and fermented milk (yoghurt, for instance), despite having a low Glycemic Index and Load, elicit a very high insulin response and this has been shown repeatedly in intervention studies^4-9.

As you may be aware, constantly increasing insulinemia may down-regulate the insulin receptor and hence lead to insulin resistance^10-12. Thisin turn is the primary metabolic defect underlying The Metabolic Syndrome¹³, and may be a driving force in Obesity^{14, 15}. It should also be mentioned that a chronic state of Hyperinsulinemia may initiate a hormonal cascade that ultimately results in Cancer, Acne and Juvenile Myopia, among other diseases¹³ (as thoroughly documented in Dr.Cordain’s scientific paper Hyperinsulinemic diseases of civilization: more than just syndrome X which you can download here.

Indeed, a high bovine milk diet has been shown to cause insulin resistance in boys⁹. Moreover, dairy intake is strongly associated with a higher incidence of Acne^16-18 and moderately associated with Prostate Cancer^19-23.

2) Cow’s milk appears to be involved in certain Autoimmune diseases (AD):

• Various epidemiological studies have associated it with Type 1 Diabetes^24-31, especially when the initial exposure begins in the first months of life.
• Epidemiological studies have repeatedly shown a strong correlation between Multiple Sclerosis and cow’s milk consumption^32-36.
• There is molecular mimicry between Bovine Serum Albumin and Human Collagen Type 1, which has implications for Rheumatoid Arthritis³⁷. Indeed, case studies have shown that elimination of milk and dairy products from the diets of patients with RA improved symptoms, and the disease was markedly exacerbated on re-challenge³⁷.
• Bovine Milk is also implicated (or appears to have adverse effects) in other auto-immune diseases, such as Crohn's disease³⁸, Sjögren's syndrome³⁹, IgA nephropathy^40-42, Behçet's disease⁴³, and even Celiac Disease⁴⁰.

3) Hormones in Milk:

In addition to proteins, fats, lactose, vitamins and minerals, Milk contains various growth-stimulating steroid and peptide hormone and also catalysts, transporters and stabilizers that ensure their maximum bioactivity⁴⁵.

Here’s a short list of some hormones present in cow’s milk that could be problematic for humans:

• Insulin
• IGF-1
• Betacellulin (BTC)
• Estrogens (particularly Estrone Sulfate)
• Precursors of Dihydrotestosterone (DHT)

Insulin

Cow’s milk, as well as human milk (and presumably milk from all mammals) contains insulin^46-49, and we know that bovine insulin - BI (which differs from human insulin by three amino acids⁵⁰) survives pasteurization, because immunity to this hormone is common in children who consume cow’s milk or who have been exposed to infant formulas containing cow’s milk^51-54.

This not only confirms that BI is present in commercial pasteurized milk, but also in infant formulas and perhaps other dairy products (although direct evidence is lacking). Moreover, these studies provide evidence that BI survives the human digestive processes and crosses the gut barrier intact, although this could be related to the fact that infants have higher intestinal permeability than older children and adults⁵⁰. Nevertheless, various factors may cause the so called "leaky gut" in virtually everyone, so we shouldn’t dismiss bovine insulin altogether.

IGF-1

Cow’s milk contains active IGF-1⁵⁵, but this has been largely dismissed as irrelevant, since pasteurization (time and temperature are crucial factors) and fermentation appears to reduce its content^{56, 57}. Yet cow’s milk consumption, compared to various foods, is associated with higher plasma IGF-1 concentrations in humans (both children^58-61 and adults^62-66, which could be due to calcium in milk (which has been shown to increase IGF-1 in boys and girls⁶⁷), the effect of milk upon insulinemia (the high elevation of plasma insulin caused by milk drinking^4-9 could lead to a higher plasma IGF-1¹³) or indeed residual IGF-1 in casein⁶⁸ (the major protein in milk).

Betacellulin

Betacellulin (BTC) belongs to the Epidermal Growth Factor family of hormones⁶⁹, and it is found not only in cow’s milk⁷⁰ and whey⁷⁰, but also in cheese⁷⁰, so it survives pasteurization and processing. Although no direct evidence exists yet, bovine milk contains peptidase inhibitors which prevent human gut enzymes from degrading EGF⁵ (and most likely BTC) and a low ph, such as may be found in the gut, does not impair or prevent BTC from binding its receptor⁷¹. Finally, there is a luminally expressed EGF receptor in the gut, through which BTC may enter circulation⁶⁹.

Steroid Hormones

The major sources of animal-derived estrogens in the human diet are believed to be milk and dairy products, which presumably account for 70–80% of the total estrogens consumed^72-73. Furthermore, it has been pointed out that most milk for human consumption is obtained from cows in the latter half of pregnancy, when estrogen metabolite levels are greatly elevated^72-74. Confirming this, US researchers have measured estrogen metabolites in various milks and found that buttermilk contains the highest total amount of estrogen metabolites, followed by skim milk, 2% milk and whole milk⁷². So, estrogen metabolites appear to survive pasteurization, and Estrone sulphate, which comprises 45% of the conjugated estrogens in Premarin and Prempro, the most frequently prescribed hormone replacement therapy for menopausal women⁷³ has high oral bioactivity⁷³ and is the most prevalent form of estrogen in cow’s milk^{72, 73}.

There are also other steroid hormones in commercial pasteurized cow’s milk, such as progesterone, 5α-androstanedione and 5α-pregnanedione that are dihydrotestosterone (DHT) precursors⁷⁵.

As expected from the evidence presented, dairy intake is strongly associated with a higher incidence of Acne^16-18, moderately associated with Prostate Cancer^19-23, and mildly associated with ovarian cancer^{76, 77}.

Dairy consumption was also associated with an increased incidence of testicular^78-79, kidney⁸⁰ and head and neck cancer⁸¹, but very few studies looking at this have been conducted to draw more significant conclusions.

Although epidemiological evidence can’t show cause and effect and clearly many more studies need to be conducted, the current evidence strongly suggests that cow’s milk may be implicated in a variety of autoimmune diseases, certain cancers, as well as Acne.

4) Milk has a very high calcium/magnesium ratio and may contribute to some micronutrient imbalances.

Finally, there is evidence of higher fracture incidence rates in countries with higher milk and calcium intake82, some long term prospective studies have failed to show a benefit from drinking milk or taking calcium supplements83-85, and a recent meta-analysis, which analyzed 7 prospective cohort studies (170 991 women), 5 prospective cohort studies (⁶⁸ 606 men), 5 clinical trials, (5666 women, and 1074 men), and 4 clinical trials with separate results for hip fracture (6504 subjects), concluded that calcium intake doesn’t decrease the risk for fractures⁸⁶. And calcium intake is only part of the story – we need to consider the GI absorption and the renal excretion, and in these regards, vegetables from the brassica family have a clear advantage over milk.

I know this may sound overly alarming and exaggerated, but given what I know about milk, I have a hard time recommending it, even though it has some positive effects, such as being a cheap source of high quality protein and various micronutrients.

For those who are fortunate and have access to good (real) food and supplements (such as Vitamin D, which, by the way, may be needed in much higher doses than the ones provided by 3 or 4 servings of dairy a day) and adopt a diet more in line with the Paleo Diet, I believe milk is not necessary.

I hope this helps.
Pedro

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