Showing posts with label milk. Show all posts
Showing posts with label milk. Show all posts

Wednesday, February 3, 2010

Paleo Diet Q & A - 3 February 2010 - Milk During Pregnancy


Dear Readers,

Today's edition of Paleo Diet Q & A focuses on consumption of milk during pregnancy.

Q: Hi Dr. Cordain,

My sister is a few weeks pregnant and has been following the Paleo Diet for a couple months now. Her doctor just told her to consume lots of milk during her pregnancy. My assumption is that they want to make sure she's getting plenty of vitamin D and calcium. I have her on a 2000 IU/day vitamin D supplement as well as a calcium/vitamin D supplement. What are your thoughts/suggestions?

Drew

A: Dear Drew,

There is good evidence that up until 9,000 years ago in the Middle East1 and 7,000 years ago in Northern Europe2, no human being on the planet consumed non-human milk or dairy products.

So, on an evolutionary time scale non-human milk is a relative newcomer to the human diet.

By using the evolutionary template, and knowing that milk is species-specific, we would expect this new habit to have unintended consequences, which go much beyond lactose intolerance, which is, actually very common, since only a minor percentage of the world’s population continues to produce lactase into adulthood3.

Indeed there are several lines of evidence raising concerns with milk and dairy intake, such as:

1) Milk and fermented milk (yoghurt, for instance), despite having a low Glycemic Index and Load, elicit a very high insulin response and this has been shown repeatedly in intervention studies4-9.

As you may be aware, constantly increasing insulinemia may down-regulate the insulin receptor and hence lead to insulin resistance10-12. Thisin turn is the primary metabolic defect underlying The Metabolic Syndrome13, and may be a driving force in Obesity14, 15. It should also be mentioned that a chronic state of Hyperinsulinemia may initiate a hormonal cascade that ultimately results in Cancer, Acne and Juvenile Myopia, among other diseases13 (as thoroughly documented in Dr.Cordain’s scientific paper Hyperinsulinemic diseases of civilization: more than just syndrome X which you can download here.

Indeed, a high bovine milk diet has been shown to cause insulin resistance in boys9. Moreover, dairy intake is strongly associated with a higher incidence of Acne16-18 and moderately associated with Prostate Cancer19-23.

2) Cow’s milk appears to be involved in certain Autoimmune diseases (AD):
  • Various epidemiological studies have associated it with Type 1 Diabetes24-31, especially when the initial exposure begins in the first months of life.
  • Epidemiological studies have repeatedly shown a strong correlation between Multiple Sclerosis and cow’s milk consumption32-36.
  • There is molecular mimicry between Bovine Serum Albumin and Human Collagen Type 1, which has implications for Rheumatoid Arthritis37. Indeed, case studies have shown that elimination of milk and dairy products from the diets of patients with RA improved symptoms, and the disease was markedly exacerbated on re-challenge37.
  • Bovine Milk is also implicated (or appears to have adverse effects) in other auto-immune diseases, such as Crohn's disease38, Sjögren's syndrome39, IgA nephropathy40-42, Behçet's disease43, and even Celiac Disease40.
3) Hormones in Milk:

In addition to proteins, fats, lactose, vitamins and minerals, Milk contains various growth-stimulating steroid and peptide hormone and also catalysts, transporters and stabilizers that ensure their maximum bioactivity45.

Here’s a short list of some hormones present in cow’s milk that could be problematic for humans:
  • Insulin
  • IGF-1
  • Betacellulin (BTC)
  • Estrogens (particularly Estrone Sulfate)
  • Precursors of Dihydrotestosterone (DHT)
Insulin

Cow’s milk, as well as human milk (and presumably milk from all mammals) contains insulin46-49, and we know that bovine insulin - BI (which differs from human insulin by three amino acids50) survives pasteurization, because immunity to this hormone is common in children who consume cow’s milk or who have been exposed to infant formulas containing cow’s milk51-54.

This not only confirms that BI is present in commercial pasteurized milk, but also in infant formulas and perhaps other dairy products (although direct evidence is lacking). Moreover, these studies provide evidence that BI survives the human digestive processes and crosses the gut barrier intact, although this could be related to the fact that infants have higher intestinal permeability than older children and adults50. Nevertheless, various factors may cause the so called "leaky gut" in virtually everyone, so we shouldn’t dismiss bovine insulin altogether.

IGF-1

Cow’s milk contains active IGF-155, but this has been largely dismissed as irrelevant, since pasteurization (time and temperature are crucial factors) and fermentation appears to reduce its content56, 57. Yet cow’s milk consumption, compared to various foods, is associated with higher plasma IGF-1 concentrations in humans (both children58-61 and adults62-66, which could be due to calcium in milk (which has been shown to increase IGF-1 in boys and girls67), the effect of milk upon insulinemia (the high elevation of plasma insulin caused by milk drinking4-9 could lead to a higher plasma IGF-113) or indeed residual IGF-1 in casein68 (the major protein in milk).

Betacellulin

Betacellulin (BTC) belongs to the Epidermal Growth Factor family of hormones69, and it is found not only in cow’s milk70 and whey70, but also in cheese70, so it survives pasteurization and processing. Although no direct evidence exists yet, bovine milk contains peptidase inhibitors which prevent human gut enzymes from degrading EGF5 (and most likely BTC) and a low ph, such as may be found in the gut, does not impair or prevent BTC from binding its receptor71. Finally, there is a luminally expressed EGF receptor in the gut, through which BTC may enter circulation69.

Steroid Hormones

The major sources of animal-derived estrogens in the human diet are believed to be milk and dairy products, which presumably account for 70–80% of the total estrogens consumed72-73. Furthermore, it has been pointed out that most milk for human consumption is obtained from cows in the latter half of pregnancy, when estrogen metabolite levels are greatly elevated72-74. Confirming this, US researchers have measured estrogen metabolites in various milks and found that buttermilk contains the highest total amount of estrogen metabolites, followed by skim milk, 2% milk and whole milk72. So, estrogen metabolites appear to survive pasteurization, and Estrone sulphate, which comprises 45% of the conjugated estrogens in Premarin and Prempro, the most frequently prescribed hormone replacement therapy for menopausal women73 has high oral bioactivity73 and is the most prevalent form of estrogen in cow’s milk72, 73.

There are also other steroid hormones in commercial pasteurized cow’s milk, such as progesterone, 5α-androstanedione and 5α-pregnanedione that are dihydrotestosterone (DHT) precursors75.

As expected from the evidence presented, dairy intake is strongly associated with a higher incidence of Acne16-18, moderately associated with Prostate Cancer19-23, and mildly associated with ovarian cancer76, 77.

Dairy consumption was also associated with an increased incidence of testicular78-79, kidney80 and head and neck cancer81, but very few studies looking at this have been conducted to draw more significant conclusions.

Although epidemiological evidence can’t show cause and effect and clearly many more studies need to be conducted, the current evidence strongly suggests that cow’s milk may be implicated in a variety of autoimmune diseases, certain cancers, as well as Acne.

4) Milk has a very high calcium/magnesium ratio and may contribute to some micronutrient imbalances.

Finally, there is evidence of higher fracture incidence rates in countries with higher milk and calcium intake82, some long term prospective studies have failed to show a benefit from drinking milk or taking calcium supplements83-85, and a recent meta-analysis, which analyzed 7 prospective cohort studies (170 991 women), 5 prospective cohort studies (68 606 men), 5 clinical trials, (5666 women, and 1074 men), and 4 clinical trials with separate results for hip fracture (6504 subjects), concluded that calcium intake doesn’t decrease the risk for fractures86. And calcium intake is only part of the story – we need to consider the GI absorption and the renal excretion, and in these regards, vegetables from the brassica family have a clear advantage over milk.

I know this may sound overly alarming and exaggerated, but given what I know about milk, I have a hard time recommending it, even though it has some positive effects, such as being a cheap source of high quality protein and various micronutrients.

For those who are fortunate and have access to good (real) food and supplements (such as Vitamin D, which, by the way, may be needed in much higher doses than the ones provided by 3 or 4 servings of dairy a day) and adopt a diet more in line with the Paleo Diet, I believe milk is not necessary.

I hope this helps.
Pedro

References:


  1. Evershed RP, Payne S, Sherratt AG, Copley MS, Coolidge J, Urem-Kotsu D, Kotsakis K, Ozdoğan M, Ozdoğan AE, Nieuwenhuyse O, Akkermans PM, Bailey D, Andeescu RR, Campbell S, Farid S, Hodder I, Yalman N, Ozbaşaran M, Biçakci E, Garfinkel Y, Levy T, Burton MM. Earliest date for milk use in the Near East and southeastern Europe linked to cattle herding. Nature. 2008 Sep 25;455(7212):528-31.
  2. Copley MS, Berstan R, Dudd SN, Docherty G, Mukherjee AJ, Straker V, Payne S, Evershed RP: Direct chemical evidence for widespread dairying in prehistoric Britain. Proceedings of the National Academy of Sciences of the United States of America 2003, 100(4):1524-1529.
  3. Swallow DM. Genetics of lactase persistence and lactose intolerance. Ann Rev Genet 2003;37:197-219
  4. Gannon MC, Nuttall FQ, Krezowski PA, Billington CJ, Parker S. The serum insulin and plasma glucose responses to milk and fruit products in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1986 Nov;29(11):784-91.
  5. Holt SH et al. An insulin index of foods: the insulin demand generated by 1000-kJ portions of common foods. Am J Clin Nutr. 1997 Nov;66(5):1264-76
  6. Ostman EM, et al. Inconsistency between glycemic and insulinemic responses to regular and fermented milk products. Am J Clin Nutr 2001;74:96 –100.
  7. Liljeberg Elmstahl H & Bjorck I. Milk as a supplement to mixed meals may elevate postprandial insulinaemia. Eur J Clin Nutr 2001; 55:994–999.
  8. Hoyt G et al. Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk. Br J Nutr. 2005 Feb;93(2):175-7
  9. Hoppe C et al. High intakes of milk, but not meat increase s-insulin and insulin resistance in 8-year-old boys. Eur J Clin Nutr. 2005 Mar;59(3):393-8
  10. Rizza RA, Mandarino LJ, Genest J, Baker BA, Gerich JE. Production of insulin resistance by hyperinsulinaemia in man. Diabetologia. 1985 Feb;28(2):70-5.
  11. Treadway JL, Whittaker J, Pessin JE. Regulation of the insulin receptor kinase by hyperinsulinism. J Biol Chem 1989;264:15136–15143
  12. DelPrato S, Leonetti F, Simonson DC, et al. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia 1994;37:1025 -1035.
  13. Cordain, l.; Eades, M.R.; Eades, M.D. Hyperinsulinemic diseases of civilization: more than just syndrome X. Comp Biochem Physiol Part A; 136:95-112, 2003
  14. Thomas DE, Elliott EJ, Baur L. Low glycaemic index or low glycaemic load diets for overweight and obesity. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005105
  15. Nishino N, Tamori Y, Kasuga M. Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1alpha induction. Kobe J Med Sci. 2007;53(3):99-106.
  16. Adebamowo, C.A. et al. High school dietary dairy intake and teenage acne. J Am Acad Dermatol; 52(2):207-14, 2005.
  17. Adebamowo, C.A. et al. Milk consumption and acne in adolescent girls. Dermatol Online J; 12(4):1, 2006.
  18. Adebamowo CA, et al. Milk consumption and acne in teenaged boys. J Am Acad Dermatol. 2008 May;58(5):787-93
  19. Kurahashi N, Inoue M, Iwasaki M, et al. Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men. Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):930-7.
  20. Mitrou PN, Albanes D, Weinstein SJ et al. A prospective study of dietary calcium, dairy products and prostate cancer risk (Finland). Int J Cancer; 120(11):2466-73, 2007.
  21. Rohrmann S, Platz EA, Kavanaugh CJ, et al. Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study. Cancer Causes Control. 2007 Feb;18(1):41-50.
  22. Gao X, LaValley MP, Tucker KL. Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis. J Natl Cancer Inst. 2005 Dec 7;97(23):1768-77.
  23. Qin LQ, Xu JY, Wang PY, Kaneko T, Hoshi K, Sato A. Milk consumption is a risk factor for prostate cancer: meta-analysis of case-control studies. Nutr Cancer.2004;48(1):22-7.
  24. Virtanen SM, Räsänen L, Ylönen K, Aro A, Clayton D, Langholz B, Pitkäniemi J, Savilahti E, Lounamaa R, Tuomilehto J, et al. Early introduction of dairy products associated with increased risk of IDDM in Finnish children. The Childhood in Diabetes in Finland Study Group. Diabetes. 1993 Dec;42(12):1786-90
  25. Kostraba JN, Cruickshanks KJ, Lawler-Heavner J, Jobim LF, Rewers MJ, Gay EC, Chase HP, Klingensmith G, Hamman RF. Early exposure to cow's milk and solid foods in infancy, genetic predisposition, and risk of IDDM. Diabetes. 1993 Feb;42(2):288-95.
  26. Fava, D.; Leslie, R.D.G.; Pozzilli, P. Relationship between dairy product consumption and incidence of IDDM in childhood in Italy. Diabetes Care 1994;17: 1488-1490,
  27. Gimeno SG, de Souza JM. IDDM and milk consumption. A case-control study in São Paulo, Brazil. Diabetes Care. 1997 Aug;20(8):1256-60.
  28. Hyppönen E, Kenward MG, Virtanen SM, Piitulainen A, Virta-Autio P, Tuomilehto J, Knip M, Akerblom HK. Infant feeding, early weight gain, and risk of type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes Care. 1999 Dec;22(12):1961-5.
  29. Kimpimäki T, Erkkola M, Korhonen S, Kupila A, Virtanen SM, Ilonen J, Simell O, Knip M. Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity. Diabetologia. 2001 Jan;44(1):63-9.
  30. Wahlberg J, Fredriksson J, Nikolic E, Vaarala O, Ludvigsson J; The ABIS-Study Group. Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children. Pediatr Diabetes. 2005 Dec;6(4):199-205.
  31. Wahlberg J, Vaarala O, Ludvigsson J; ABIS-study group. Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children. Br J Nutr. 2006 Mar;95(3):603-8.
  32. Agranoff BW, Goldberg D . Diet and the geographical distribution of multiple sclerosis. Lancet 1974;2:1061-66
  33. Butcher PJ. Milk consumption and multiple sclerosis--an etiological hypothesis. Med Hypotheses. 1986 Feb;19(2):169-78
  34. Malosse D et al. Correlation between milk and dairy product consumption and multiple sclerosis prevalence: a worldwide study. Neuroepidemiology. 1992;11(4-6):304-12.
  35. Malosse D, Perron H. Correlation analysis between bovine populations, other farm animals, house pets, and multiple sclerosis prevalence. Neuroepidemiology. 1993;12(1):15-27
  36. Lauer K. Diet and multiple sclerosis. Neurology. 1997 Aug;49(2 Suppl 2):S55-61.
  37. Cordain L, Toohey L, Smith MJ, Hickey MS. Modulation of immune function by dietary lectins in rheumatoid arthritis. Brit J Nutr 2000, 83:207-217.
  38. van den Bogaerde J et al. Immune sensitization to food, yeast and bacteria in Crohn's disease. Aliment Pharmacol Ther. 2001 Oct;15(10):1647-53
  39. Lidén M, Kristjánsson G, Valtysdottir S, Venge P, Hällgren R. Cow's milk protein sensitivity assessed by the mucosal patch technique is related to irritable bowel syndrome in patients with primary Sjögren's syndrome. Clin Exp Allergy. 2008 Jun;38(6):929-35.
  40. Fornasieri A, Sinico RA, Maldifassi P, Paterna L, Benuzzi S, Colasanti G, D'Amico G. Food antigens, IgA-immune complexes and IgA mesangial nephropathy. Nephrol Dial Transplant. 1988;3(6):738-43.
  41. Yap HK, Sakai RS, Woo KT, Lim CH, Jordan SC. Detection of bovine serum albumin in the circulating IgA immune complexes of patients with IgA nephropathy. Clin Immunol Immunopathol. 1987 Jun;43(3):395-402.
  42. Soylu A, Kasap B, Soylu OB, Türkmen M, Kavukçu S. Does feeding in infancy effect the development of IgA nephropathy? Pediatr Nephrol. 2007 Jul;22(7):1040-4
  43. Triolo G, Accardo-Palumbo A, Dieli F, Ciccia F, Ferrante A, Giardina E, Licata G. Humoral and cell mediated immune response to cow's milk proteins in Behçet's disease. Ann Rheum Dis. 2002 May;61(5):459-62
  44. Kristjansson G, Venge P, Hallgren R. Mucosal reactivity to cow’s milk protein in coeliac disease. Clin Exp Immunol 2007;147:449–55
  45. Walzem RL, Dillard CJ, German JB. Whey components: millennia of evolution create functionalities for mammalian nutrition: what we know and what we may be overlooking. Crit Rev Food Sci Nutr. 2002 Jul;42(4):353-75
  46. Ballard FJ, Nield MK, Francis GL, Dahlenburg GW, Wallace JC. The relationship between the insulin content and inhibitory effects of bovine colostrum on protein breakdown in cultured cells. J Cell Physiol. 1982 Mar;110(3):249-54
  47. Malven PV, Head HH, Collier RJ, Buonomo FC. Periparturient changes in secretion and mammary uptake of insulin and in concentrations of insulin and insulin-like growth factors in milk of dairy cows. J Dairy Sci. 1987 Nov;70(11):2254-65
  48. Oda S, Satoh H, Sugawara T, Matsunaga N, Kuhara T, Katoh K, Shoji Y, Nihei A, Ohta M, Sasaki Y. Insulin-like growth factor-I, GH, insulin and glucagon concentrations in bovine colostrum and in plasma of dairy cows and neonatal calves around parturition. Comp Biochem Physiol A Comp Physiol. 1989;94(4):805-8
  49. Aranda P, Sanchez L, Perez MD, Ena JM, Calvo M. Insulin in bovine colostrum and milk: evolution throughout lactation and binding to caseins. J Dairy Sci. 1991 Dec;74(12):4320-5
  50. Vaarala O. Is it dietary insulin? Ann N Y Acad Sci. 2006 Oct;1079:350-9
  51. Vaarala O, Paronen J, Otonkoski T, A ° Kerblom HK. Cow milk feeding induces antibodies to insulin in children—a link between cow milk and insulin-dependent diabetes mellitus? Scand J Immunol 1998: 47: 131–135.
  52. Vaarala O, Knip M, Paronen J et al. Cow’s milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes 1999: 48: 1389–1394.
  53. Paronen, J. et al. The effect of cow milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Diabetes 2000;49: 1657–1665.
  54. Vaarala, O. et al. The effect of coincident enterovirus infection and cow’s milk exposure on immunization to insulin in early infancy. Diabetologia 2002; 45:531–534.
  55. Blum JW, Baumrucker CR. Insulin-Like Growth Factors (IGFs), IGF Binding Proteins, and Other Endocrine Factors in Milk: Role in the Newborn. In Bosze Z. Bioactive Components of Milk, Springer, 2008, Pgs 397-422
  56. Collier RJ, Miller MA, Hildebrandt JR, Torkelson AR, White TC, Madsen KS, Vicini JL, Eppard PJ, Lama GM. Factors affecting insulin-like growth factor-I concentration in bovine milk. J Dairy Sci 1991; 74:2905-2911.
  57. Kang SH, Kim JU, Imm JY, Oh S, Kim SH. The effects of dairy processes and storage on insulin-like growth factor-I (IGF-I) content in milk and in model IGF-I–fortified dairy products. J Dairy Sci 2006; 89:402-409.
  58. Hoppe C, Mølgaard C, Michaelsen KF. Cow's milk and linear growth in industrialized and developing countries. Annu Rev Nutr. 2006;26:131-73.
  59. Rogers IS, Gunnell D, Emmett PM, et al. Cross-sectional associations of diet and insulin-like growth factor levels in 7- to 8-yearold children. Cancer Epidemiol Biomarkers Prev 2005; 14: 204-212.
  60. Hoppe C, Udam TR, Lauritzen L, et al. Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-yold Danish children. Am J Clin Nutr 2004; 80: 447-452.
  61. Hoppe C, Mølgaard C, Juul A, et al. High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. Eur J Clin Nutr 2004; 58: 1211-1216.
  62. Ma J, Giovannucci E, Pollak M, et al. Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. J Natl Cancer Inst 2001, 93:1330-1336.
  63. Giovannucci E, Pollak M, Liu Y, et al. Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. Cancer Epidemiol Biomarkers Prev 2003, 12:84-89.
  64. Norat T, Dossus L, Rinaldi S, et al. Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women. Eur J Clin Nutr 2007; 61: 91-98.
  65. Morimoto LM, Newcomb PA, White E, et al. Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: personal and lifestyle factors (United States). Câncer Causes Control 2005; 16: 917-927.
  66. Holmes MD, Pollak MN, Willett WC, et al. Dietary correlates of plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 concentrations. Cancer Epidemiol Biomarkers Prev 2002; 11: 852-861
  67. Ginty F, et al. calcium carbonate supplementation is associated with higher plasma IGF-1 in 16-to 18-year old boys and girls. In Burckhardt P, Heaney R, Dawson-Hughes B. Nutritional Aspects of Osteoporosis. Elsevier, 2004, pp 45-57
  68. Hoppe C, Mølgaard C, Dalum C, Vaag A, Michaelsen KF. Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. Eur J Clin Nutr. 2009 Sep;63(9):1076-83
  69. Cordain L. Dietary implications for the development of acne: a shifting paradigm. In: U.S. Dermatology Review II 2006, (Ed.,Bedlow, J). Touch Briefings Publications, London, 2006.
  70. Bastian SE, et al. Measurement of betacellulin levels in bovine serum, colostrum and milk. J Endocrinol. 2001 Jan;168(1):203-12
  71. Rao RK, Baker RD, Baker SS. Bovine milk inhibits proteolytic degradation of epidermal growth factor in human gastric and duodenal lumen. Peptides. 1998; 19(3):495-504
  72. Farlow DW, Xu X, Veenstra TD. Quantitative measurement of endogenous estrogen metabolites, risk-factors for development of breast cancer, in commercial milk products by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 31. [Epub ahead of print]
  73. Ganmaa D, Sato A. The possible role of female sex hormones in milk from pregnant cows in the development of breast, ovarian and corpus uteri cancers. Med Hypotheses 2005; 65: 1028-37
  74. Qin LQ, Wang PY, Kaneko T, et al. Estrogen: one of the risk factors in milk for prostate cancer. Med Hypotheses. 2004;62(1):133-42.
  75. Danby FW. Acne, dairy and cancer. Dermato-Endocrinology 1:1, 9-13; January/February 2009.
  76. Genkinger JM, Hunter DJ, Spiegelman D, et al. Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):364-72.
  77. Larsson SC, Orsini N, Wolk A. Milk, milk products and lactose intake and ovarian cancer risk: a meta-analysis of epidemiological studies. Int J Cancer. 2006 Jan 15;118(2):431-41.
  78. Stang, A.; Ahrens, W.; Baumgardt-Elms, C. et al. Adolescent milk fat and galactose consumption and testicular germ cell cancer. Cancer Epidemiol Biomarkers Prev; 15(11):2189-95, 2006.
  79. Ganmaa D, Li XM, Qin LQ, et al. The experience of Japan as a clue to the etiology of testicular and prostatic cancers. Med Hypotheses. 2003 May;60(5):724-30.
  80. Bravi F, Bosetti C, Scotti L, et al. Food groups and renal cell carcinoma: a case-control study from Italy. Int J Cancer. 2007 Feb 1;120(3):681-5.
  81. Peters ES, Luckett BG, Applebaum KM, Marsit CJ, McClean MD, Kelsey KT. Dairy products, leanness, and head and neck squamous cell carcinoma. Head Neck. 2008 Sep;30(9):1193-205.
  82. Klompmaker TR. Lifetime high calcium intake increases osteoporotic fracture risk in old age. Med Hypotheses. 2005;65(3):552-8
  83. Owusu W, Willett WC, Feskanich D, Ascherio A, Spiegelman D, Colditz GA. Calcium intake and the incidence of forearm and hip fractures among men. J Nutr 1997; 127:1782-7.
  84. Feskanich D, Willett W et al. Milk, Dietary Calcium, and Bone Fractures in Women: A 12-Year Prospective Study. Am J Public Health. 1997 Jun;87(6):992-7.
  85. Feskanich D, Willett WC, Colditz GA. Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women. Am J Clin Nutr. 2003 Feb;77(2):504-11.
  86. Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, Burckhardt P, Li R, Spiegelman D, Specker B, Orav JE, Wong JB, Staehelin HB, O'Reilly E, Kiel DP, Willett WC. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr. 2007 Dec;86(6):1780-90.

Tuesday, February 2, 2010

Paleo Diet Q & A - 2 February 2010 - The Paleo Diet and Children


Dear Readers,

Today's Paleo Diet Q & A focuses on use of the diet for children.



Q: Thanks for all of the hard work your team puts into this. I've been receiving the e-mail blog for quite some time, have read both Paleo Diet and Paleo Diet for Athletes books, and subscribe to a Yahoo Paleo blog as well. I thoroughly enjoy reading the information sent to me every few days including the archives.

One concern I do have is that the bulk of the information seems to be targeted toward adults. More specifically adults with health problems that have already occurred and are in many cases not being addressed or cured by "traditional" medical practices. As the kids grow I feel it is important to develop proper dietary habits now, not when they are older and dealing with the after effects of poor health.

In my personal case I have a young son who has had issues with asthma. We have sought medical help but my mind keeps coming back to the Paleo Diet. Is there more detailed information available to address the issues of babies, young children and some of the issues they deal with as they mature?

Again, thanks for the great job.
Murray

A: Hi Murray,

The subject of pregnancy, young children, and The Paleo Diet was discussed in Volume 5 Issue 24 of our newsletter, The Paleo Diet Update. Here is the full text of that article:

Pregnancy, Young Children, and the Paleo Diet
by Loren Cordain, Ph.D.

With the growing popularity of the Paleo Diet, we've received questions about adapting this diet for pregnancy, particularly with regard to the low fat aspect of the diet. Others are also asking for more information about adapting the Paleo Diet to the growth and nutritional needs of infants and young children. With a little modification, the Paleo Diet can meet these needs, help children escape the growing childhood obesity problem, build life-long eating habits to lower the risk of disease, and generate healthful, vital longevity. Here are some recommendations for using the Paleo Diet to optimize nutrition during pregnancy, infancy and childhood.

What about pregnancy?

Due to the metabolic changes that occur in the liver during pregnancy, women cannot tolerate protein levels as high as they normally could. This has been documented in both the anthropological and clinical literature. To accommodate this, higher fat meats, higher fat vegetables, and more carbs can be included in the Paleo Diet during pregnancy than most people eating the typical Paleo Diet will need.

Numerous studies have shown that fetal and infant cognitive development requires sufficient omega-3 fatty acids during pregnancy and nursing. Our ancestors got most of their dietary fat from leaner meat, which was a richer source of monounsaturated and omega-3 polyunsaturated fatty acids, than the meat from feedlot animals today. The Paleo Diet is high in mono-unsaturated fats, such as olive oil, and omega-3 polyunsaturated fats from fish. It also avoids feedlot meat to increase the omega-3 in our diet, and enhance the omega-6/omega-3 ratio to more closely resemble the healthful diet of our ancestors.

What about infancy (the first two years of a child's life)?

Hunter-gatherer children were typically introduced to solid food later than what is considered normal in the Western world. Studies of five hunter-gatherer societies (Kung, Ache, Inuit, Australian Aborigines, and Hadza) have revealed the average age of weaning to be 2.9 years. Hence, the early nutrition of hunter-gatherer infants is highly dependent upon mother's milk. Because hunter-gatherers typically consumed a diet higher in omega-3 fatty acids, mother's milk likely would also have been higher in omega-3 fatty acids than milk from the typical nursing Western mother. This difference is important in light of the studies indicating the importance of sufficient omega-3 fatty acids during pregnancy and nursing for cognitive development. For the Western mother, weaning at age 3 is impractical, but weaning should be delayed as long as possible (preferrably at least 1-1.5 years). After weaning, I recommend that infants be given a formula th at is enriched with both docosahexaenoic acid (DHA) and arachidonic acid (AA). Infants should not be given eicosapentaenoic acid (EPA) in the form of fish oil because it competes with AA metabolism and can result in impaired motor development and growth.

Human milk contains very little iron, but infants are born with iron stores sufficient to last 9-12 months. Pediatricians typically recommend that infants' first solid foods be iron-fortified cereals. Commercial baby foods, such as beef, pork, or chicken, are a better alternative to this. Hunter-gatherer mothers introduced their infants to solid foods by thoroughly chewing meat, marrow, nuts, seeds, fruits, etc. If you do give cereal to your infant, I recommend rice and not either wheat or oats.

Virtually all pediatricians recommend that cow's milk and other dairy products, such as yogurt, cheese, etc., be excluded from infant diets during their first year. Early exposure to dairy products has been implicated in increased risk of a number of autoimmune diseases, particularly type 1 diabetes.

What about when solid foods are introduced?

When switching to solid foods, I recommend focusing upon the same basic food types that I recommend for adults, such as fresh fruits and vegetables, fresh meats and seafood. There is evidence that the children's livers are less able to deal with high levels of protein (~30-40 % total energy). Hence, higher fat meats and fish should not necessarily be restricted to the same extent as with adults because this will help balance the protein levels. Higher fat plant foods, such as nuts and avocados, and healthful oils are also useful, but monitor for nut allergies. Omega-3 enriched eggs should be the egg of choice, and they are a source of DHA.

I don't advocate completely restricting processed food from children because eating involves behavioral issues. The best way to get a child to eat junk food is to completely forbid it. In our house, we serve typical Paleo foods in every meal. We stock very little processed food, so if our children are hungry, their choices are primarily healthy foods. We don't allow unlimited access to TV, computers or electronic games, but we do encourage outdoor play. For active children, I don't think that certain high glycemic load foods may be harmful. We do not restrict dried fruit, such as raisins and dates, and we encourage them to eat bananas, yams and sweet potatoes.

Finally, while societies often view being tall positively, it has a downside. It increases the adult risk for a number of cancers, particularly breast cancer in women. The nature of this relationship remains obscure, but our research group thinks that the relationship between stature and cancer risk involves the consumption of high glycemic load carbohydrates during childhood, along with an otherwise healthy diet that is high in protein. I fully explain how high glycemic load carbohydrates can increase height and risk of numerous chronic diseases in my published research article # 24. Cordain L, Eades MR, Eades MD. Hyperinsulinemic diseases of civilization: more than just syndrome X.

Please visit our web site to obtain a copy of Volume 5 Issue 24 of The Paleo Diet Update for a complete list of the references cited in this article.



Dr. Cordain has also written the following comments:

The American Pediatric Society recommends that cow’s milk not be given in the first year ,and a number of studies indicate that it increases the risk for type I diabetes and other autoimmune diseases later in life. I have 3 boys (17, 15, 11) and none of them have ever consumed milk on a regular basis – In fact they rarely or never drink it. They eat cheese and ice cream occasionally, but certainly not daily or even once a week. The 17 yr old is a lean, high level high school swimmer and is 5’10”, 138 lbs. The 15 year old is 6’1” and 145 lbs and plays competitive ice hockey; the 11 year old is 5’4” about 95 lbs and plays all sports. None of them wears glasses, or have ever had acne & among them all there have only been 2 dental caries. We are not strict with the Paleo diet for them, but we never have stocked our house with bread, crackers, milk, candy, soda or processed foods. At every meal we provide a variety of fresh fruits, vegetables, meats, seafood and omega 3 enriched eggs. They eat potatoes, sweet potatoes, and some rice & some processed foods like sushi, beef jerky, fruit popsicles, tacos and other minimally processed foods. All parents want to give their children the best start possible. Our anecdotal successes may not be right for everyone, but they have worked for us.

Loren Cordain, Ph.D.



In addition, Pedro has the following commentary:

During the first year of life, you should give a child human milk or a completely hydrolyzed infant formula (one study used a casein-based commercially available formula in children with high risk for Type 1 Diabetes).

Milk and dairy not only increase the risk for Type 1 Diabetes when consumed early in life, but they are also associated with various auto-immune diseases. Moreover, milk elevates insulin as much as white bread (having been shown to induce insulin resistance in boys) and it increases IGF-1 and decreases IGFBP-3, which is a hormonal pattern implicated in various cancers (prostate, breast, kidney, liver, etc.), myopia and acne.

Finally, milk proteins (especially alpha casein s1 and beta-lactoglobulin, which do not exist in human milk) are common food allergens, and milk is a source of various hormones (commercial milk from pregnant cows and cows who have mastitis and/or are intensively fed to gain weight rapidly have an even higher concentration of some of these hormones). This is another possible mechanism linking milk with hormonal dependent cancers. There various other reasons why I think non-human milk is not ideal for humans, but I tried to present the most important ones.

I know this may sound overly alarming and exaggerated, but given what I know about milk, I have a hard time recommending it, even though it has some positive effects.

In my opinion, the main benefit of milk is that it is a cheap source of high quality protein and various micronutrients. So, for those who are fortunate and have access to good food, milk is not necessary.

Instead of milk, I would continue using a completely hydrolysed formula (like the one used in the Type 1 Diabetes study – make sure it contains DHA and arachidonic acid [AA], or supplement your child's diet with DHA and give them egg yolks to get AA).

If you don’t have a choice and feel like you have to give them milk, I would opt for non-homogenized fermented goat milk (or goat yoghurt), which has much less alpha casein s1 than cow’s milk, and it may contain smaller concentrations of various steroid and peptide hormones. This is because it is fermented, the animal is smaller, and they aren’t typically treated like a cow.

Nevertheless, it most certainly will elevate insulin as much as cow’s milk does, and it will have an impact on the IGF-1 system. Moreover, apart from alpha casein s1, the protein profile of goat milk is similar to cow milk, so the possibility exists that it may also elicit an autoimmune response in some people. Also, there are reports in the medical literature of selective allergy to goat milk. Finally, both milks have a high calcium/magnesium ratio, and may contribute to some micronutrient imbalances.

Pedro

Wednesday, December 2, 2009

Paleo Diet Q & A - 2 December 2009


Dear Readers,

Here's today's edition of Paleo Diet Q & A.



Q: I'm a beginner with the Paleo Diet. I want to try it out but I'm a vegetarian (I eat tofu, seitan, tempeh, fish, eggs, and cheese as replacements for meat). I understand I have to leave out the beans, but is it ok to use the rest of the replacements ? Thank you for an answer.

A: The Paleo Diet is based on foods similar to what our hunter-gatherer ancestors ate during the paleolithic era 2.6 million year to 10,000 years ago. That translates into 99.6 % of our evolution history. Our genome is perfectly adapted to eat foods similar to what we found during that period of time. This means eating lean meats, seafood, vegetables, fruits, and nuts. The agricultural revolution (10,000 years ago) lead to a dramatic change in human nutrition. Cereal grains, legumes, dairy, vegetable oils, salt, alcohol, and refined sugars comprise 72% of the nutrition in the modern western society. These foods contain harmful substances associated to many "diseases of civilization", such as diabetes, celiac disease and other autoimmune diseases, obesity, hypertension, certain cancers, acne, polycistic ovary syndrome, myopia, dyslipidemia, cardiovascular disease, etc.

Tofu and tempeh are sources of soy bean agglutinin (SBA). SBA has harmful properties because they break cell membranes. This can induce increased intestinal permeability, which is associated to certain autoimmune diseases and low-grade inflammation. SBA has also been shown to stimulate the immune system, something we don't want in an inflammatory disease.

Seitan contains the worst part of wheat namely gluten. Gluten is a prolamine peptide associated to many diseases typical of western civilization, such as celiac disease, type 1 diabetes, multiple sclerosis, ataxia, rheumatoid arthritis, etc.

So, if you want to eat a paleolithic diet without eating meat you should ensure a good protein intake using egg powder protein shakes along with some supplements:
  • Vitamin B12 1 mg per day
  • Taurine 1 gram per day
  • Carnosine 800 mg per day
  • Carnitine 400 mg per day



Q: Hi I'm about to have a child, and I don't want to bring it up on a diet of sugar and wheat. Do you have any research for children and the Paleo Diet?

A: No, there aren't any clinical trials for children and The Paleo Diet. However, the current advice for infant nutrition comes from nutritional boards who base their views on:
  1. Western human diet observations.
  2. Randomized controlled trials with single nutrients in a western setting.
  3. Extrapolation of observation in western adults to infants.
This means these recommendations are not based on the evolutionary template, which dictates our metabolic and physiological needs.

For example, recommendations for formula milk composition are the opposite of what research on hunter-gatherer mothers' milk has found. Current recommendations for formula milk state that Linoleic acid content should be high, and saturated fats such as Lauric and Myristic acid should be low. This is the contrary to what we find in mothers on the island of Chole in Tanzania who eat fish, vegetables, fruits and nuts, and turns out that these people are free of "diseases of civilization".

Wednesday, November 18, 2009

Paleo Diet Q & A - 11.18.09


Dear Readers,

Here's today's edition of Q & A from the Paleo Diet community. Thanks to those of you who've left questions and comments in reply to these posts. Our team is currently reviewing all outstanding questions and will have answers to post soon.



Q: My question is regarding the consumption of milk. There are a great number of coaches around the country who advocate at least moderate, if not generous, amounts of milk in their athletes' diets. Does it not provide a good source of protein and carbohydrate balance, not to mention the calcium content? What is the paleo stance on milk and why?

A: There are several reasons why not to consume dairy products:

Hominids evolved during 2.6 million years behaving as hunter-gatherers.

Although there wasn’t a single diet, and diet rather varied by latitude, season, climate, culture, etc., all ancestral diets shared key characteristics. Food sources were limited to unprocessed foraged plants, and unprocessed land and marine animals hunted from the proximate environment. As such, human diets consisted of combinations of wild animal carcasses (including brains, bone marrow, and organs), shellfish, fish, fruits, leafy vegetables, mushrooms, insects, larvae, nuts, seasonal honey, and eggs.

Ten thousand years ago, major changes in the environment happened, including the human diet. New foods, such as cereal grains, legumes, dairy, vegetable oils, refined sugars, fatty domesticated meats and salt, were introduced.

Since that time, there is strong evidence that our genome has remained essentially unchanged over the past 10,000 years. Evolutionary medicine predicts that these environmental changes may have caused adverse effects.

Indeed, it is believed that this mismatch between our ancient genome and the modern environment (including our modern diet) is at the root of the so-called diseases of western civilization, such as type 2 diabetes, obesity, dislipidemia, hypertension, certain types of cancer, acne, autoimmune diseases, myopia, polycystic ovary syndrome and more.

Regarding dairy, we know that this food group was not available for human intake prior to the onset of animal husbandry--roughly 9,000 years ago in the Middle East, and 7,000 years ago in Northern Europe. So dairy is a relatively new food on an evolutionary time scale, which explains why it may produce the following adverse effects, through different mechanisms:
  • Milk is a source of estrogens and dihydrotestosterone precursors, which can increase the risk of certain cancers and acne.
  • Milk increases IGF-1, and the IGF-1/IGFBP-3 ratio, and this increases the risk of certain cancers and acne--among other diseases--as explained by Dr. Cordain in his 2003 paper “Hyperinsulinemic diseases of civilization: more than just syndrome X” (http://www.thepaleodiet.com/articles/Hyperinsulinemic%20Diseases%20Final.pdf)
  • Milk contains insulin, and bovine insulin differs in only 3 amino acids from human insulin. This feature can increase the risk of Type 1 diabetes in genetically susceptible persons.
  • Betacellulin: is a hormone belonging to the EGF family of hormones. If it is confirmed that Betacellulin is able to enter circulation, then there is a very good possibility that it may increase the susceptibility of certain epithelial cancers.
  • Milk elevates insulin as much as white bread. Constantly elevating plasma insulin levels may lead to insulin resistance, which is at the root of several metabolic diseases such as obesity, type 2 diabetes or hypertension.
  • High calcium intake adversely affects zinc absorption, a key mineral in more than 300 enzymatic reactions.
  • Milk contains several allergenic proteins.
  • Dairy products, especially hard cheeses, yield a very high net acidic load which might lead to calcium and muscle loss and decrease growth hormone.
In sports nutrition BCAA intake is crucial for muscle recovery. Lean meat is the biggest sources of BCAA (33 grs/1000Kcal). Dairy contains much less BCAA (12 grs/1000Kcal), so if you replace lean meats with dairy you are taking much less BCAA which is crucial in muscle recovery.



Q: I was diagnosed with ulcerative colitis about 3 years ago. It started off as a very mild case but recently progressed to the point where my doctor was discussing having my colon removed if a new medication (Remicade) did not work. Being on Remicade has helped, and I was able to put 20 pounds back on. However, I do not believe in medication alone. I believe that diet is a key component to living a healthy life. I follow the Paleo Diet which has helped tremendously. I know that there are certain foods like night shade vegetables, which are part of the Paleo Diet, that I should avoid. Is there any other foods on the Paleo Diet that I should eliminate?

A: Yes, autoimmune patients should make some changes regarding The Paleo Diet:
  • Nightshade (potatoes, eggplants, peppers and tomatoes) should be removed from your diet as they contain harmful lectins and saponins.
  • Egg white is a source of a membranolytic (breaks cell membranes) protein--namely Lisozyme--and therefore should also be removed from your diet.
  • Remember that soy beans derived products, as well as peanuts, are legumes. They should be removed from your diet.
  • Another harmful nutrients are quinoa, amaranth and root beer.
You can find more info in our "How to Treat MS with Diet" program, which is available from our website: http://www.thepaleodiet.com/store.shtml.